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Article

The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression.

Cancer medicine - 1 Sept 2026

Bracken-Clarke Dara, Xue Elisabetta, Krause Harris, Adeyelu Tolulope, Evans Mark G, Akbulut Dilara, Quezado Martha, Gandhi Nishant, Farrell Alex, Soares Heloisa P, Lou Emil, Phan Minh, Patel Rusha, Vanderwalde Ari M, Elliott Andrew, Steuer Conor E, Saba Nabil F, Lubin Daniel J, London Nyall R, Gulley James L, Floudas Charalampos S

Abstract excerpt

Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV-positive and in EBV-negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile...

Read the complete abstract on PubMed

Topics

Humans
Receptors, Somatostatin
Female
Nasopharyngeal Carcinoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Microenvironment

Nasopharyngeal Neoplasms

Male

Middle Aged

Gene Expression Regulation, Neoplastic

Biomarkers, Tumor

Gene Expression Profiling

Adult

Mutation

Aged

Epstein-Barr Virus Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 42670259
DOI: 10.1002/cam4.72239
PMCID: PMC13527533

Genes

SSTR2
CYLD
NFKBIA
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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