Article

Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic neuroendocrine tumors (PNETs) are a rare and understudied set of cancers, with increasing incidence. Neuroendocrine tumors are unique in the fact that they express high levels of the somatostatin receptor type 2 (SSTR2), which represents a target for both tumor imaging and therapeutics. PNET grade inversely correlates with SSTR2 tumor staining and higher tumor grade is associated with...

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Literature Corpus work: f6ecdce8-fe0b-5733-8bf2-1109632d52e8
DOI: 10.1101/2025.09.23.677935

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