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Cellular Senescence: Molecular Mechanisms, <i>In Vivo</i> Significance, and Redox Considerations

2 Nov 2008

Abstract excerpt

Cellular senescence is recognized as a critical cellular response to prolonged rounds of replication and environmental stresses. Its defining characteristics are arrested cell-cycle progression and the development of aberrant gene expression with proinflammatory behavior. Whereas the mechanistic events associated with senescence are generally well understood at the molecular level, the impact of senescence in...

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PMID: 18976161
DOI: 10.1089/ars.2008.2104

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