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Article

A Lactate Fermentation Mutant of Toxoplasma Stimulates Protective Immunity Against Acute and Chronic Toxoplasmosis.

Frontiers in immunology - 1 Jan 2018

Xia Ningbo, Zhou Taifang, Liang Xiaohan, Ye Shu, Zhao Pengfei, Yang Jichao, Zhou Yanqin, Zhao Junlong, Shen Bang

Abstract excerpt

Toxoplasma gondii is an important zoonotic pathogen infecting one-third of the world's population and numerous animals, causing significant healthcare burden and socioeconomic problems. Vaccination is an efficient way to reduce global sero-prevalence, however, ideal vaccines are not yet available. We recently discovered that the Toxoplasma mutant lacking both lactate dehydrogenases LDH1 and LDH2 (Δldh) grew well...

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Identifiers

PMID: 30147689
DOI: 10.3389/fimmu.2018.01814
PMCID: PMC6096001

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