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Article

Optimizing DNA transduction by selection of mutations that evade bacterial defense systems.

RNA biology - 1 Apr 2019

Auster Oren, Globus Rea, Yosef Ido, Qimron Udi

Abstract excerpt

We recently developed a platform where phage-transducing particles optimize DNA delivery to a wide range of hosts. Here, we use this platform to optimize DNA transduction into hosts that naturally restrict specific DNA sequences. We first show that a specific plasmid is restricted for transduction into a particular Salmonella strain. Using the platform, we select for a mutated plasmid that overcomes the...

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Share to Base Sequence
Share to DNA, Bacterial
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immune Evasion

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Share to Plasmids

Share to Reproducibility of Results

Share to Transduction, Genetic

Source

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Identifiers

PMID: 30146918
DOI: 10.1080/15476286.2018.1514235
PMCID: PMC6546373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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