Article
Interaction between the microbiome and TP53 in human lung cancer.
Genome biology - 24 Aug 2018
Greathouse K Leigh, White James R, Vargas Ashely J, Bliskovsky Valery V, Beck Jessica A, von Muhlinen Natalia, Polley Eric C, Bowman Elise D, Khan Mohammed A, Robles Ana I, Cooks Tomer, Ryan Bríd M, Padgett Noah, Dzutsev Amiran H, Trinchieri Giorgio, Pineda Marbin A, Bilke Sven, Meltzer Paul S, Hokenstad Alexis N, Stickrod Tricia M, Walther-Antonio Marina R, Earl Joshua P, Mell Joshua C, Krol Jaroslaw E, Balashov Sergey V, Bhat Archana S, Ehrlich Garth D, Valm Alex, Deming Clayton, Conlan Sean, Oh Julia, Segre Julie A, Harris Curtis C
Abstract excerpt
BACKGROUND: Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer, reduces epithelial barrier integrity and increases susceptibility to infections. Herein, we hypothesize that somatic mutations together with cigarette smoke generate a dysbiotic microbiota that is associated with lung carcinogenesis....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.