Article
Unveiling the distinctive variations in multi-omics triggered by TP53 mutation in lung cancer subtypes: An insight from interaction among intratumoral microbiota, tumor microenvironment, and pathology.
Computational biology and chemistry - 1 Dec 2024
Tong Shanhe, Huang Kenan, Xing Weipeng, Chu Yuwen, Nie Chuanqi, Ji Lei, Wang Wenyan, Tian Geng, Wang Bing, Yang Jialiang
Abstract excerpt
The TP53 mutation is one of the most common gene mutations in non-small cell lung cancer (NSCLC) and plays a significant role in the occurrence, development, and prognosis of both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Recent studies have also suggested the predictive value of TP53 mutations in the response to immunotherapy for NSCLC. It is known that intratumoral microbiota, tumor...
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