Article
Role of IL-6/RORC/IL-22 axis in driving Th17 pathway mediated immunopathogenesis of schizophrenia.
Cytokine - 1 Nov 2018
Subbanna Manjula, Shivakumar Venkataram, Talukdar Pinku Mani, Narayanaswamy Janardhanan C, Venugopal Deepthi, Berk Michael, Varambally Shivarama, Venkatasubramanian Ganesan, Debnath Monojit
Abstract excerpt
The immuno-inflammatory origin of schizophrenia in a subset of patients is viewed as a key element of an overarching etiological construct. Despite substantial research, the immune components exerting major effect are yet to be fully clarified. Disrupted T cell networks have consistently been linked to the pathogenesis of schizophrenia. Amongst the Th cell subsets, the Th17 cells have emerged as a paradigmatic...
Topics
- Adolescent
- Adult
- Female
- Genotype
- Humans
- Immune System Diseases
- Interleukin-6
- Interleukins
- Male
- Middle Aged
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Polymorphism, Single Nucleotide
- Schizophrenia