Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.

Journal of medicinal chemistry - 13 Sept 2018

Miller Mark, Pal Arindom, Albusairi Wabel, Joo Hyun, Pappas Beverly, Haque Tuhin Md Tariqul, Liang Dengpan, Jampala Raghavendra, Liu Fang, Khan Jared, Faaij Marjon, Park Miki, Chan William, Graef Isabella, Zamboni Robert, Kumar Neil, Fox Jonathan, Sinha Uma, Alhamadsheh Mamoun

Abstract excerpt

Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a fatal disease with no available disease-modifying therapies. While pathogenic TTR mutations (TTRm) destabilize TTR tetramers, the T119M variant stabilizes TTRm and prevents disease. A comparison of potency for leading TTR stabilizers in clinic and structural features important for effective TTR stabilization is lacking. Here, we found that molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Amyloid Neuropathies, Familial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Benzoates

Share to Biomimetics

Share to Entropy

Share to Prealbumin

Share to Protein Stability

Share to Pyrazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 30133284
DOI: 10.1021/acs.jmedchem.8b00817
PMCID: PMC6276790

Genes

TTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.PMID 30133284Read ↗

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation.Semantic proximity Read ↗

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.Semantic proximity Read ↗

Pathogenic Characterization of a Novel G47R Transthyretin Mutation in Early-Onset Amyloid Cardiomyopathy.Semantic proximity Read ↗

Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis.Semantic proximity Read ↗

Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics.Semantic proximity Read ↗

Transthyretin (ATTR) amyloidosis nephropathy: lessons from a TTR stabilizer molecule.Semantic proximity Read ↗

Clinical and Biochemical Characterization of Hereditary ATTR Amyloidosis Caused by a Novel Transthyretin Variant V121A (p.V141A)Semantic proximity Read ↗

Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology.Semantic proximity Read ↗

Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin.Semantic proximity Read ↗

Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy.Semantic proximity Read ↗

Modulating conformational factors in transthyretin amyloid.Semantic proximity Read ↗

A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.