Article
Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy.
Virchows Archiv : an international journal of pathology - 1 Apr 2019
Menter Thomas, Tzankov Alexandar
Abstract excerpt
Chromosome 9 harbors several relevant oncogenes related to hematolymphoid malignancies and one specific region, 9p24, has come into the focus of attention in the last years as it contains recurrently mutant genes of therapeutic interest. The most prominent genes of this locus are programmed death ligands 1 and 2 (PDL1/PDL2), with the amplification of PDL1 being a hallmark of both classical Hodgkin and primary...
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