Article
MET-overexpressing myxofibrosarcoma frequently exhibit polysomy of chromosome 7 but not MET amplification, especially in high-grade cases: clinical and pathological review of 30 myxofibrosarcoma cases.
Diagnostic pathology - 21 Aug 2018
Ma Shirong, Fan Linni, Liu Yixiong, Wang Yingmei, Yu Kangjie, Wang Lifeng, Fang Na, Liu Fang, Guo Shuangping, Wang Zhe
Abstract excerpt
BACKGROUND: Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas. Previous studies have shown that MET protein overexpressed in MFS patients and can serve as a prognostic factor. The reasons for MET protein overexpression include amplification of the MET gene, which is located on chromosome 7q. Triggered by an index case harboring chromosome 7 polysomy rather than MET gene amplification in...
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