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Detection of MET Polysomy by Next-generation Sequencing and Its Clinical Relevance for MET Inhibitors

6 Mar 2023

Abstract excerpt

Next-generation sequencing (NGS) has failed to detect mesenchymal epithelial transition factor gene (MET) polysomy in previous studies. We included three non–small cell lung cancer (NSCLC) cohorts in this retrospective study to establish new criteria for detecting MET polysomy and to explore the clinical relevance of MET polysomy. Cohort 1 included 53 patients whose tissues were available for both FISH and NGS...

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PMID: 37025355
DOI: 10.1158/2767-9764.crc-22-0438

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