Article
Search of Somatic Mutations of NKX2-5 and GATA4 Genes in Chinese Patients with Sporadic Congenital Heart Disease.
Pediatric cardiology - 1 Jan 2019
Yin Jie, Qian Jianhua, Dai Genyin, Wang Chunli, Qin Yuming, Xu Ting, Li Zewei, Zhang Han, Yang Shiwei
Abstract excerpt
Congenital heart disease (CHD) usually occurs sporadically, with only a minority of cases associated with a known genetic mechanism. Cardiac-specific transcription factors NKX2-5 and GATA4 play key roles in the mammalian heart development, and the affected cardiac tissues of CHD patients are prone to somatic mutations which thus participate in the pathogenesis of CHD. We collected 98 patients with sporadic CHD,...
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