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Senescence and senotherapeutics: a new field in cancer therapy

16 Aug 2018

Abstract excerpt

Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer. Due to the lack of a reliable marker able to detect senescence in vivo, its precise impact...

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PMID: 30121319
DOI: 10.1016/j.pharmthera.2018.08.006

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