Article
Enhanced ROS production leads to excessive fat accumulation through DAF-16 in Caenorhabditis elegans.
Experimental gerontology - 2 Oct 2018
Wang Kejie, Chen Sixi, Zhang Congjie, Huang Jiatao, Wu Jia, Zhou Huaibin, Jin Liqin, Qian Xu, Jin Jinlong, Lyu Jianxin
Abstract excerpt
Growing evidence shows that enhanced reactive oxygen species (ROS) production is an important contributor to obesity and its co-morbidities, but the functional link between ROS and obesity remains elusive. In this study we used the model animal Caenorhabditis elegans to explore the role of ROS in obesity. Initially, when ROS production was enhanced by treatment with low concentration of paraquat or juglone, both...
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