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Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA ‐mutant GIST s

17 Aug 2018

Abstract excerpt

PDGFRA mutations in the gastrointestinal (GI) tract can cause GI stromal tumour (GIST) and inflammatory fibroid polyp (IFP). Hitherto no cell type has been identified as a physiological counterpart of the latter, while interstitial Cajal cells (ICC) are considered the precursor of the former. However, ICC hyperplasia (ICCH), which strongly supports the ICC role in GIST pathogenesis, has been identified in...

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PMID: 30117724
DOI: 10.1111/jcmm.13748

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