Article
[Detection of UGT1A1*6 single nucleotide polymorphism in oral swap samples using the cascade invader assay-based real-time PCR].
Yi chuan = Hereditas - 16 Aug 2018
Zhang Jie Yu, Chu Ya Nan, Zou Bing Jie, Zhang Yan Jie, Feng Li Ying
Abstract excerpt
The adverse reaction to irinotecan is related to the single nucleotide polymorphism (SNP) of UGT1A1*6 genotype. The current SNP detection methods have various disadvantages, including time-consuming procedures, high- risk cross-contamination, and cumbersome operation. Hence, it is necessary to establish a new method suitable for clinical application, which is easy and simple to detect SNP with minimal risk for...
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