Article
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.
Scientific reports - 8 Nov 2016
Colvin Hugh, Nishida Naohiro, Konno Masamitsu, Haraguchi Naotsugu, Takahashi Hidekazu, Nishimura Junichi, Hata Taishi, Kawamoto Koichi, Asai Ayumu, Tsunekuni Kenta, Koseki Jun, Mizushima Tsunekazu, Satoh Taroh, Doki Yuichiro, Mori Masaki, Ishii Hideshi
Abstract excerpt
Deranged metabolism is a hallmark of cancer, playing a significant role in driving the disease process. One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH) occurring in subsets of leukaemias and brain tumours. The oncogenic property of D-2HG appears to stem from its ability to interfere with...
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