Article
The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration.
eLife - 14 Aug 2018
L'honoré Aurore, Commère Pierre-Henri, Negroni Elisa, Pallafacchina Giorgia, Friguet Bertrand, Drouin Jacques, Buckingham Margaret, Montarras Didier
Abstract excerpt
Skeletal muscle regeneration depends on satellite cells. After injury these muscle stem cells exit quiescence, proliferate and differentiate to regenerate damaged fibres. We show that this progression is accompanied by metabolic changes leading to increased production of reactive oxygen species (ROS). Using Pitx2/3 single and double mutant mice that provide genetic models of deregulated redox states, we...
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