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Article

Loss of Parkin Results in Altered Muscle Stem Cell Differentiation during Regeneration

28 Oct 2020

Abstract excerpt

The high capacity of the skeletal muscle to regenerate is due to the presence of muscle stem cells (MuSCs, or satellite cells). The E3 ubiquitin ligase Parkin is a key regulator of mitophagy and is recruited to mitochondria during differentiation of mouse myoblast cell line. However, the function of mitophagy during regeneration has not been investigated in vivo. Here, we have utilized Parkin deficient...

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PMID: 33126429
DOI: 10.3390/ijms21218007

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