Article
First-trimester prenatal diagnosis of severe alpha-thalassemia.
Prenatal diagnosis - 1 Jan 2000
Wang L M, Zhang J W, Wu G Y, Wang S W, Fan Y u, Huang Y W, Zhao L T, Wang R X, Su J D, Zhang N J
Abstract excerpt
By means of chorion biopsy together with restriction endonuclease analysis of fetal DNA, first trimester diagnoses were successfully made in 33 fetuses at risk for Bart's hydrops fetalis. Seven pregnancies with Hb H or hydrops fetalis were therapeutically terminated before 4 1/2 months of gestati...
Topics
- Biopsy
- Chorionic Villi
- Chromosome Mapping
- DNA Restriction Enzymes
- Edema
- Female
- Genotype
- Humans
- Pregnancy
- Pregnancy Trimester, First
- Prenatal Diagnosis
- Thalassemia
- Trophoblasts