Article
Prenatal diagnosis of sickle cell anemia and beta-thalassemia by amniocentesis.
Texas reports on biology and medicine - 1 Jan 2000
Phillips J A
Abstract excerpt
Prenatal diagnosis by amniocentesis alone is possible for about 90% of pregnancies at risk for sickle cell anemia and about 70-75% of pregnancies at risk for beta-thalassemia. It should be stressed that to obtain these percentages, a previous homozygous normal or affected child or, alternatively, the couple's parents are needed to confirm the linkage of variant genes to respective DNA markers (polymorphic...
Topics
- Amniocentesis
- Anemia, Sickle Cell
- DNA Restriction Enzymes
- Female
- Fetoscopy
- Genes
- Genetic Linkage
- Humans
- Mutation
- Polymorphism, Genetic
- Pregnancy
- Pregnancy Complications, Hematologic