Article
Alpha thalassemia major--new mutations, intrauterine management, and outcomes.
Hematology. American Society of Hematology. Education Program - 1 Jan 2009
Vichinsky Elliott P
Abstract excerpt
Alpha thalassemia disorders are a group of hereditary anemias caused by absent or decreased production of the alpha chain of hemoglobin. Hemoglobin Bart's hydrops fetalis is usually a fatal in-utero disease caused by absence of the alpha genes. However, the molecular and genotypic expression of hemoglobin Bart's varies and increasing numbers of births are being reported. Population screening and prenatal...
Topics
- Abnormalities, Multiple
- Adult
- Asia
- Blood Transfusion, Intrauterine
- Female
- Fetal Diseases
- Gene Deletion
- Hemoglobins, Abnormal
- Humans
- Hydrops Fetalis
- Infant, Newborn
- Mutation