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Article

Distinct amino acid motifs carrying multiple positive charges regulate membrane targeting of dysferlin and MG53.

PloS one - 1 Jan 2018

Zhou Lu, Middel Volker, Reischl Markus, Strähle Uwe, Nienhaus G Ulrich

Abstract excerpt

Dysferlin (Dysf) and mitsugumin53 (MG53) are two key proteins involved in membrane repair of muscle cells which are efficiently recruited to the sarcolemma upon lesioning. Plasma membrane localization and recruitment of a Dysf fragment to membrane lesions in zebrafish myofibers relies on the presence of a short, polybasic amino acid motif, WRRFK. Here we show that the positive charges carried by this motif are...

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Identifiers

PMID: 30092031
DOI: 10.1371/journal.pone.0202052
PMCID: PMC6084962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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