Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.

Cancer research - 15 Oct 2018

Bayley Rachel, Blakemore Daniel, Cancian Laila, Dumon Stephanie, Volpe Giacomo, Ward Carl, Almaghrabi Ruba, Gujar Jidnyasa, Reeve Natasha, Raghavan Manoj, Higgs Martin R, Stewart Grant S, Petermann Eva, García Paloma

Abstract excerpt

Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by blood cytopenias that occur as a result of somatic mutations in hematopoietic stem cells (HSC). MDS leads to ineffective hematopoiesis, and as many as 30% of patients progress to acute myeloid leukemia (AML). The mechanisms by which mutations accumulate in HSC during aging remain poorly understood. Here we identify a novel role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Comet Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Repair

Share to Hematopoietic Stem Cells

Share to Myelodysplastic Syndromes

Share to Radiation, Ionizing

Share to Trans-Activators

Source

Identifiers

PMID: 30082276
DOI: 10.1158/0008-5472.CAN-18-0273

Genes

MYBL2
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.PMID 30082276Read ↗

MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.Semantic proximity Read ↗

MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesisSemantic proximity Read ↗

The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromesSemantic proximity Read ↗

Myb-like, SWIRM, and MPN domains 1 (MYSM1) deficiency: Genotoxic stress-associated bone marrow failure and developmental aberrations.Semantic proximity Read ↗

Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDSSemantic proximity Read ↗

The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion.Semantic proximity Read ↗

Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of DyserythropoiesisSemantic proximity Read ↗

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibitionSemantic proximity Read ↗

Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes.Semantic proximity Read ↗

Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.Semantic proximity Read ↗

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.