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Article

Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

30 Jul 2018

Abstract excerpt

Recent studies indicate that nucleoli play critical roles in the DNA-damage response (DDR) via interaction of DDR machinery including NBS1 with nucleolar Treacle protein, a key mediator of ribosomal RNA (rRNA) transcription and processing. Here, using proteomics, confocal and single molecule super-resolution imaging, and infection under biosafety level-4 containment, we show that this nucleolar DDR pathway is...

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PMID: 30076298
DOI: 10.1038/s41467-018-05354-7

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