Article
Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control
1 Aug 2024
Abstract excerpt
Viral genomes are enriched with G-quadruplexes (G4s), non-canonical structures formed in DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of their critical roles, G4s are potential antiviral targets, yet their function remains largely unknown. Here, we characterize the formation and functions of a conserved G4 within the polymerase coding region of orthoflaviviruses of the...
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