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Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans

5 Oct 2017

Abstract excerpt

ABSTRACT While progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little is known regarding the corresponding T cell responses to ZIKV. Here, we investigate the kinetics and viral epitopes targeted by T cells responding to ZIKV and address the critical question of whether preexisting dengue virus (DENV) T cell immunity modulates these responses. We find that memory T cell...

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PMID: 28978707
DOI: 10.1128/jvi.01469-17

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