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Article

Treatment of β654 -thalassaemia by TALENs in a mouse model.

Cell proliferation - 1 Dec 2018

Fang Yudan, Cheng Yan, Lu Dan, Gong Xiuli, Yang Guanheng, Gong Zhijuan, Zhu Yiwen, Sang Xiao, Fan Shuyue, Zhang Jingzhi, Zeng Fanyi

Abstract excerpt

OBJECTIVES: This study explored whether TALENs-mediated non-homologous end joining (NHEJ) targeting the mutation site can correct the aberrant β-globin RNA splicing, and ameliorate the β-thalassaemia phenotype in β654 mice. MATERIAL AND METHODS: TALENs vectors targeted to the human β-globin gene (HBB) IVS2-654C >T mutation in a mouse model were constructed and selected to generate double heterozygous TALENs+...

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Source

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Identifiers

PMID: 30070404
DOI: 10.1111/cpr.12491
PMCID: PMC6528953

Genes

HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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