Article
Two NAD-independent l-lactate dehydrogenases drive l-lactate utilization in Pseudomonas aeruginosa PAO1.
Environmental microbiology reports - 1 Oct 2018
Wang Yujiao, Xiao Dan, Liu Qiuyuan, Zhang Yipeng, Hu Chunxia, Sun Jinkai, Yang Chunyu, Xu Ping, Ma Cuiqing, Gao Chao
Abstract excerpt
Pseudomonas aeruginosa often establishes a chronic infection in the airways of patients with cystic fibrosis (CF). l-Lactate is the most abundant carbon source in the CF sputum, and l-lactate utilization may be important for P. aeruginosa to survive in the lungs of CF patients. In this study, the key enzymes involved in l-lactate utilization by P. aeruginosa PAO1 were characterized using the synthetic CF sputum...
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