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Article

Phase I Study Evaluating the Combination of Afatinib with Carboplatin and Pemetrexed After First-line EGFR-TKIs.

Anticancer research - 1 Aug 2018

Watanabe Satoshi, Yamaguchi O U, Masumoto A I, Maeno Yuri, Kawashima Yosuke, Ishimoto Osamu, Sugawara Shunichi, Yoshizawa Hirohisa, Kikuchi Toshiaki, Nukiwa Toshihiro, Kobayashi Kunihiko

Abstract excerpt

BACKGROUND/AIM: Promising reports have described the combination of first-generation epidermal growth factor receptor tyrosine-kinase inhibitors (EGFR-TKIs) with carboplatin plus pemetrexed or bevacizumab. However, no analysis of afatinib with platinum-doublet chemotherapies has been performed. PATIENTS AND METHODS: We evaluated the safety and antitumor efficacy of afatinib combined with carboplatin and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30061238
DOI: 10.21873/anticanres.12776

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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