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A phase 2 trial combining afatinib with cetuximab in patients with EGFR exon 20 insertion-positive non-small cell lung cancer.

Cancer - 1 Mar 2024

van Veggel Bianca A M H, van der Wekken Anthonie J, Paats Marthe S, Hendriks Lizza E L, Hashemi Sayed M S, Daletzakis Antonios, van den Broek Daan, Bosch Linda J W, Monkhorst Kim, Smit Egbert F, de Langen Adrianus J

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations are the third most common EGFR mutations in patients with non-small cell lung cancer (NSCLC) and are associated with primary resistance to EGFR tyrosine kinase inhibitors (TKIs). There is evidence of activity of combining EGFR TKIs with monoclonal antibodies. This study reports on the efficacy and safety of afatinib in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37905752
DOI: 10.1002/cncr.35090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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