Article
St6gal1 knockdown alters HBV life cycle in HepAD38 cells.
Biochemical and biophysical research communications - 10 Sept 2018
Priyambada Surya Agung, Misaki Ryo, Okamoto Toru, Ohashi Takao, Ueda Keiji, Matsuura Yoshiharu, Fujiyama Kazuhito
Abstract excerpt
Complex glycans at the cell surface play important roles, and their alteration is known to modulate cellular activity. Previously, we found that HBV replication in HepAD38 altered cell-surface sialylated N-glycan through the upregulation of St6gal1, Mgat2, and Mgat4a expression. Here we studied the effects of knocking them down on HBV replication in HepAD38. Our results showed that St6gal1 knockdown (KD) reduced...
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