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Assembling multiple xenoprotective transgenes in pigs

28 Jul 2018

Abstract excerpt

This review gives a brief overview of the genetic modifications necessary for grafted porcine tissues and organs to overcome rejection in human recipients. It then focuses on the problem of generating and breeding herds of donor pigs carrying modified endogenous genes and multiple xenoprotective transgenes. A xenodonor pig optimised for human clinical use could well require the addition of ten or more...

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PMID: 30055014
DOI: 10.1111/xen.12431

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