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Article

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

PLoS pathogens - 1 Jul 2018

Bristol Jillian A, Djavadian Reza, Albright Emily R, Coleman Carrie B, Ohashi Makoto, Hayes Mitchell, Romero-Masters James C, Barlow Elizabeth A, Farrell Paul J, Rochford Rosemary, Kalejta Robert F, Johannsen Eric C, Kenney Shannon C

Abstract excerpt

Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell malignancies. However, whether lytic EBV infection also contributes to tumors is unclear, although the association between malaria infection and Burkitt lymphomas (BLs) may involve excessive lytic EBV replication. A particular variant of the viral promoter (Zp) that controls lytic EBV reactivation is over-represented,...

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Share to Epstein-Barr Virus Infections
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Immune Cell Function and Interaction

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 30052684
DOI: 10.1371/journal.ppat.1007179
PMCID: PMC6082571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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