Article
The Frequency of SF3B1 Mutations in Thai Patients with Myelodysplastic Syndrome
Asian Pacific journal of cancer prevention : APJCP - 27 Jul 2018
Rujirachaivej Punchita, Siriboonpiputtana Teerapong, Rerkamnuaychoke Budsaba, Magmuang Suthada, Chareonsirisuthigul Takol, Boonsakan Paisarn, Petvises Sawang, Sirirat Tanasan, Niparuck Pimjai, Chuncharunee Suporn
Abstract excerpt
Genetic mutations in genes encoding critical component of RNA splicing machinery including SF3B1 are frequently identified and recognized as the pathogenesis in the development of myelodysplatic syndrome (MDS). In this study, PCR sequencings specific for SF3B1 exon 13, 14, 15, and 16 were performed to analyse genomic DNA isolated from bone marrow samples of 72 newly diagnosed MDS patients. We found that 10 of 72...
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