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Article

A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2026

Wu Zhongshou, Liu Lu, Han Wenyu, Cai Xingbo, Xiao Pixian, Sun Zuodong, Yan Chunsheng, Reid Silvana, Chen Yun, Ma Zhonghua, Tang Yi, Jacobsen Steven E

Abstract excerpt

Cellulose, a primary component of plant cell walls, is synthesized by cellulose synthase complexes (CSCs) at the plasma membrane. Targeting this process with cellulose biosynthesis inhibitors (CBIs) has significantly advanced our understanding of plant cell wall formation and provided valuable compounds for herbicide development. Here, we identified a fungal natural product, 8-methyldichlorodiaporthin (MDD), as a...

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PMID: 42263129
DOI: 10.1073/pnas.2602575123
PMCID: PMC13273347

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