Effects of CYP3A5 and UGT2B7 variants on steady-state carbamazepine concentrations in Chinese epileptic patients.

doi:10.1097/MD.0000000000011662

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Effects of CYP3A5 and UGT2B7 variants on steady-state carbamazepine concentrations in Chinese epileptic patients.

Medicine - 1 Jul 2018

Lu Qiong, Huang Yuan-Tao, Shu Yi, Xu Ping, Xiang Da-Xiong, Qu Qiang, Qu Jian

Abstract excerpt

Carbamazepine (CBZ) is a widely used antiepileptic drug with large interindividual variability in serum concentrations. Previous studies found that CYP3A5*3 (rs776746), UGT2B7*2 (802C>T), and UGT2B7*3 (211G>T) variants could change the enzymes' activity, which may influence drug concentrations. Our study aims to investigate whether these variants affect steady-state CBZ concentrations in Chinese epileptic...

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PMID: 30045320
DOI: 10.1097/MD.0000000000011662
PMCID: PMC6078657

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