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Article

The Mutational Landscape of PTK7 in Congenital Scoliosis and Adolescent Idiopathic Scoliosis.

Genes - 12 Nov 2021

Su Zhe, Yang Yang, Wang Shengru, Zhao Sen, Zhao Hengqiang, Li Xiaoxin, Niu Yuchen, Deciphering Disorders Involving Scoliosis And COmorbidities Disco Study Group, Qiu Guixing, Wu Zhihong, Wu Nan, Zhang Terry Jianguo

Abstract excerpt

Depletion of ptk7 is associated with both congenital scoliosis (CS) and adolescent idiopathic scoliosis (AIS) in zebrafish models. However, only one human variant of PTK7 has been reported previously in a patient with AIS. In this study, we systemically investigated the variant landscape of PTK7 in 583 patients with CS and 302 patients with AIS from the Deciphering Disorders Involving Scoliosis and COmorbidities...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34828397
DOI: 10.3390/genes12111791
PMCID: PMC8619039

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