Article
Conformational response to charge clustering in synthetic intrinsically disordered proteins.
Biochimica et biophysica acta. General subjects - 1 Oct 2018
Tedeschi Giulia, Salladini Edoardo, Santambrogio Carlo, Grandori Rita, Longhi Sonia, Brocca Stefania
Abstract excerpt
BACKGROUND: Recent theoretical and computational studies have shown that the charge content and, most importantly, the linear distribution of opposite charges are major determinants of conformational properties of intrinsically disordered proteins (IDPs). Charge segregation in a sequence can be measured through κ, which represents a normalized measure of charge asymmetry. A strong inverse correlation between κ...
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