Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2018

Sundar Raghav, McVeigh Terri, Dolling David, Petruckevitch Ann, Diamantis Nikolaos, Ang Joo Ern, Chenard-Poiriér Maxime, Collins Dearbhaile, Lim Joline, Ameratunga Malaka, Khan Khurum, Kaye Stan B, Banerji Udai, Lopez Juanita, George Angela J, de Bono Johann S, van der Graaf Winette T

Abstract excerpt

BACKGROUND: Adolescent and young adult (AYA) patients with advanced solid tumours are often considered for phase I clinical trials with novel agents. The outcome of AYAs in these trials have not been described before. AIM: To study the outcome of AYA patients in phase I clinical trials. METHODS: Clinical trial data of AYAs (defined as aged 15-39 years at diagnosis) treated at the Drug Development Unit, Royal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Fatigue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Nausea

Share to Outcome Assessment, Health Care

Share to Proto-Oncogene Proteins p21(ras)

Share to Tumor Suppressor Protein p53

Share to Vomiting

Source

Identifiers

PMID: 30025230
DOI: 10.1016/j.ejca.2018.06.003

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials.PMID 30025230Read ↗

The role of genomic profiling in adolescents and young adults (AYAs) with advanced cancer participating in phase I clinical trials.Semantic proximity Read ↗

Adolescent and young adult patients with cancer: a milieu of unique features.Semantic proximity Read ↗

Unique Challenges in Sarcoma Care for Adolescents and Young Adults.Semantic proximity Read ↗

Adolescent and Young Adult Cancer BiologySemantic proximity Read ↗

Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis.Semantic proximity Read ↗

Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA ExpressionSemantic proximity Read ↗

Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug AdministrationSemantic proximity Read ↗

Associations of Age With Tumor Genomic Characteristics in Relapsed/Refractory Cancers Interrogated With the NCI-MATCH Trial Targeted Gene Panel Assay.Semantic proximity Read ↗

Age-dependent molecular variations in osteosarcoma: implications for precision oncology across pediatric, adolescent, and adult patientsSemantic proximity Read ↗

Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trialSemantic proximity Read ↗

Outcomes for children with recurrent/refractory atypical teratoid rhabdoid tumor: A single institution study with molecular correlationSemantic proximity Read ↗

How to Treat INI1 Negative Non-Rhabdoid Tumours in Adolescents: Following Genotype or Histological Phenotype?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.