Article
The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation.
Journal of molecular biology - 21 Sept 2012
Hammer Neal D, McGuffie Bryan A, Zhou Yizhou, Badtke Matthew P, Reinke Ashley A, Brännström Kristoffer, Gestwicki Jason E, Olofsson Anders, Almqvist Fredrik, Chapman Matthew R
Abstract excerpt
Curli are functional amyloids produced by enteric bacteria. The major curli fiber subunit, CsgA, self-assembles into an amyloid fiber in vitro. The minor curli subunit protein, CsgB, is required for CsgA polymerization on the cell surface. Both CsgA and CsgB are composed of five predicted β-strand-loop-β-strand-loop repeating units that feature conserved glutamine and asparagine residues. Because of this...
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