Article
Role of Escherichia coli curli operons in directing amyloid fiber formation.
Science (New York, N.Y.) - 1 Feb 2002
Chapman Matthew R, Robinson Lloyd S, Pinkner Jerome S, Roth Robyn, Heuser John, Hammar Marten, Normark Staffan, Hultgren Scott J
Abstract excerpt
Amyloid is associated with debilitating human ailments including Alzheimer's and prion diseases. Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid. The CsgA curlin subunit, purified in the absence of the CsgB nucleator, adopted a soluble, unstructured form that upon prolonged incubation assembled into fibers that were indistinguishable from...
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