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Article

Growth inhibition of KRAS‑ and EGFR‑mutant lung adenocarcinoma by cosuppression of STAT3 and the SRC/ARHGAP35 axis.

Oncology reports - 1 Sept 2018

Onodera Ken, Sakurada Akira, Notsuda Hirotsugu, Watanabe Tatsuaki, Matsuda Yasushi, Noda Masafumi, Endo Chiaki, Okada Yoshinori

Abstract excerpt

The need for effective treatment of KRAS‑mutant lung cancer is an emerging issue. Rho GTPase‑activating protein 35 (ARHGAP35) is reported to be a possible molecular target for lung adenocarcinoma. We investigated the effect of long‑term ARHGAP35 suppression on the proliferation, migration and molecular dynamics of lung adenocarcinomas harboring KRAS and EGFR gene mutations. Lung adenocarcinoma cell lines A549...

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Source

Identifiers

PMID: 30015929
DOI: 10.3892/or.2018.6536

Genes

ARHGAP35
KRAS
STAT3
SRC
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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