Article
Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis.
Nature genetics - 1 Aug 2018
Kowalec Kaarina, Wright Galen E B, Drögemöller Britt I, Aminkeng Folefac, Bhavsar Amit P, Kingwell Elaine, Yoshida Eric M, Traboulsee Anthony, Marrie Ruth Ann, Kremenchutzky Marcelo, Campbell Trudy L, Duquette Pierre, Chalasani Naga, Wadelius Mia, Hallberg Pär, Xia Zongqi, De Jager Philip L, Denny Joshua C, Davis Mary F, Ross Colin J D, Tremlett Helen, Carleton Bruce C
Abstract excerpt
Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-β (IFN-β). Up to 60% of IFN-β-exposed MS patients develop abnormal biochemical liver test results1,2, and 1 in 50 experiences drug-induced liver injury3. Since genomic variation contributes to other forms of drug-induced liver injury4,5, we aimed to identify biomarkers of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.