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Article

Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.

International journal of molecular sciences - 16 Jul 2018

Lafite Pierre, André François, Graves Joan P, Zeldin Darryl C, Dansette Patrick M, Mansuy Daniel

Abstract excerpt

The influence of Arginine 117 of human cytochrome P450 2J2 in the recognition of ebastine and a series of terfenadone derivatives was studied by site-directed mutagenesis. R117K, R117E, and R117L mutants were produced, and the behavior of these mutants in the hydroxylation of ebastine and terfenadone derivatives was compared to that of wild-type CYP2J2. The data clearly showed the importance of the formation of a...

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Source

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Identifiers

PMID: 30012976
DOI: 10.3390/ijms19072066
PMCID: PMC6073854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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