Article
State of art and limitations in genetic engineering to induce stable chondrogenic phenotype.
Biotechnology advances - 15 Nov 2018
Graceffa Valeria, Vinatier Claire, Guicheux Jerome, Evans Christopher H, Stoddart Martin, Alini Mauro, Zeugolis Dimitrios I
Abstract excerpt
Current protocols for chondrocyte expansion and chondrogenic differentiation of stem cells fail to reduce phenotypic loss and to mitigate hypertrophic tendency. To this end, cell genetic manipulation is gaining pace as a means of generating cells with stable chondrocyte phenotype. Herein, we provide an overview of candidate genes that either induce cartilage regeneration or inhibit cartilage degeneration. We...
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