Article
Adapting ISFETs for Epigenetics: An Overview.
IEEE transactions on biomedical circuits and systems - 1 Oct 2018
Ma Dora, Rodriguez-Manzano Jesus, de Mateo Lopez Sara, Kalofonou Melpomeni, Georgiou Pantelis, Toumazou Christofer
Abstract excerpt
This paper gives an overview of how CMOS design methods can be applied to ion-sensitive field effect transistor (ISFETs) for pH-based DNA methylation and miRNA detection. Design specifications are fundamentally defined by the choice of analysis. As such, the focus for DNA methylation was on developing front-end analogue circuits to carry out Methylation-specific PCR (MSP) for Point-of-Care applications, and...
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