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Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells

28 Jun 2018

Abstract excerpt

We show that a human pluripotent stem cell (hPSC) population cultured on a low-adhesion substrate developed two hPSC subtypes with different colony morphologies: flat and domed. Notably, the dome-like cells showed higher active proliferation capacity and increased several pluripotent genes' expression compared with the flat monolayer cells. We further demonstrated that cell-matrix adhesion mediates the...

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PMID: 30008324
DOI: 10.1016/j.stemcr.2018.06.003

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