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Article

Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells

10 Jul 2018

Abstract excerpt

Genome-editing technologies are currently being translated to the clinic. However, cellular effects of the editing machinery have yet to be fully elucidated. Here, we performed global microarray-based gene expression measurements on human CD34 + hematopoietic stem and progenitor cells that underwent editing. We probed effects of the entire editing process as well as each component individually, including...

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Identifiers

PMID: 30005866
DOI: 10.1016/j.ymthe.2018.06.002

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